Immune profiling of pediatric solid tumors
نویسندگان
چکیده
منابع مشابه
Preface: The Status of Pediatric Solid Tumors
Despite the progress of the past few decades in treating pediatric solid tumors, patients who present with these tumors continue to present challenges. We have collected “state-of-the-science” reviews for selected solid tumors occurring in children. Almost 24 years ago we wrote a review, “New Insights into the causes of Cancer” for a volume devoted to Solid Tumors in Children that was published...
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Recently, a subpopulation of cells, termed tumor-initiating cells or tumor stem cells (TSC), has been identified in many different types of solid tumors. These TSC, which are typically more resistant to chemotherapy and radiation compared to other tumor cells, have properties similar to normal stem cells including multipotency and the ability to self-renew, proliferate, and maintain the neoplas...
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PURPOSE To develop new therapies for children with solid tumors, we tested the cytotoxicity of natural killer (NK) cells expanded by coculture with K562-mb15-41BBL cells. We sought to identify the most sensitive tumor subtypes, clarify the molecular interactions regulating cytotoxicity, and determine NK antitumor potential in vivo. EXPERIMENTAL DESIGN We tested in vitro cytotoxicity of expand...
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When immune cells infiltrate tumors in large numbers, patients do better. Now researchers aim to harness this immune response to predict outcomes. The Society for Immunotherapy of Cancer (SITC) in Milwaukee is coordinating an international effort to validate Immunoscore, an assay that quantifies this immune response. If added to the current tumor–node–metastasis (TNM) cancer staging system, it ...
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Malignant solid tumors represent about 50% of all malignant neoplasm in children aged less than 15 years ,They make more than 80% of all malignancies in infants. To focus on clinical and biological characteristics of patients with various types of malignant solid tumors who have been admitted to the Oncology center at Basra Maternity and Children Hospital during the period from the 1st of Janua...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2020
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci137181